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[Acanthamoeba spp.] [Balamuthia mandrillaris] [Naegleria fowleri] [Sappinia spp.]

Sappinia is a genus of free-living amebae rarely isolated from human specimens.  The genus is found worldwide and has been isolated in the feces of many animals, including mammals and reptiles.  Cysts and trophozoites both possess two nuclei.

A

A: Four trophozoites (yellow arrows) of S. diploidea in brain tissue, stained with hematoxylin and eosin (H&E).  In three of the amebae, the two nuclei can easily be seen.