The acute phase (invasion and migration) may be marked by diarrhea, abdominal pain, fever, cough, urticaria, hepatosplenomegaly, pulmonary abnormalities, and eosinophilia.
During the chronic phase, pulmonary manifestations include cough, expectoration of discolored sputum, hemoptysis, and chest radiographic abnormalities.
Extrapulmonary locations of the adult worms result in more severe manifestations, especially when the brain is involved.
Diagnosis is based on
microscopic demonstration of eggs in stool or sputum, but these are not present until 2 to 3
months after infection. (Eggs are also occasionally encountered in effusion fluid or
biopsy material.) Concentration techniques may be necessary in patients with light
infections. Biopsy may allow diagnostic confirmation and species identification when
an adult or developing fluke is recovered.
is the drug of choice to treat paragonimiasis. Bithionol is an
alternative drug for treatment of this disease.
* This drug is approved by the FDA, but considered investigational for this purpose.