Diagnostic Findings [Last Modified: ]
Malaria
[Plasmodium falciparum] [Plasmodium knowlesi] [Plasmodium malariae] [Plasmodium ovale] [Plasmodium vivax]
Causal Agent Life Cycle Geographic Distribution Clinical Features Laboratory Diagnosis Treatment

In developing schizonts of P. knowlesi, Sinton and Mulligan's stippling may be observed.  The nucleus continues to divide until there are up to 16 (average 10) merozoites.  As the schizont matures, it fills the host RBC and the pigment collects into one or a few masses.  In the mature schizont, the merozoites may appear 'segmented' and the pigment has collected into a single mass.

Plasmodium knowlesi schizonts

A

A: Schizonts of P. knowlesi.  Figs. 16-23: Increasingly mature schizonts.
Illustrations from: Coatney GR, Collins WE, Warren M, Contacos PG. The Primate Malarias. Bethesda: U.S. Department of Health, Education and Welfare; 1971.

Plasmodium knowlesi schizont in thin blood smear Plasmodium knowlesi schizont in thin blood smear
B C

B, C: Mature schizonts of P. knowlesi in a thin blood smear from a patient that traveled to the Philippines.  Note also a ring-form trophozoite to the right of the schizont in Figure C. Images courtesy of the Wadsworth Center, New York State Department of Health.

Plasmodium knowlesi schizont in thin blood smear Plasmodium knowlesi schizont in thin blood smear
D E

D: Developing schizont of P. knowlesi in a thin blood smear from the same patient seen in Figures B and C.
E: Mature schizont of P. knowlesi in a thin blood smear from the same patient seen in Figures B-D.

 

Back Top