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Free-living Amebic Infections
[Acanthamoeba spp.] [Balamuthia mandrillaris] [Naegleria fowleri] [Sappinia spp.]

The cysts of Balamuthia mandrillaris are typically 10-25 µm in diameter.  The cysts have two walls: a wrinkled fibrous outer wall (exocyst) and an inner wall (endocyst) that may be hexagonal, spherical, star-shaped or polygonal.  Cysts contain only one nucleus with a large karyosome.  Cysts may be found in the brain, eyes, skin, lungs and other organs.

B. mandrillaris cyst in brain tissue, H&E B. mandrillaris cyst in brain tissue, H&E

A

B

A, B: Cysts of B. mandrillaris in brain tissue, stained with hematoxylin and eosin (H&E).

B. mandrillaris cyst in brain tissue, H&E B. mandrillaris cyst in brain tissue, H&E

C

D

C, D: Cysts of B. mandrillaris in brain tissue, stained with H&E.  Images courtesy of the University of Kentucky Hospital, Lexington, Kentucky.

B. mandrillaris cysts in brain tissue, H&E B. mandrillaris cyst in brain tissue, H&E

E

F

E, F: Cysts of B. mandrillaris in brain tissue, stained with H&E.  Images courtesy of Cook Children’s Hospital, Fort Worth, Texas.

 
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